The trail grew in it's significance and was used extensively by the military during the Civil War. While opening the southwest to trade, the route ran through what was referred to as "Comancheria", the open plains country of the Comanche Indians and traders found it also profitable trading with the Comanche's along the route. The Comanche's also felt they should be given gifts for allowing the trail to cross their homeland. The Comanche's, who were considered superior warriors, were a big factor in the region just as Texas settlers found out further south. The Santa Fe Trail also opened up the southwest to massive emigration. This was further exemplified by the later Atchison Topeka and Santa Fe Railroad which did so much for the growth of Santa Fe and helping it become an artists community. The railroad brought travelers to this area of northern New Mexico along with Fred Harvey, the famous hospitality mogul, whose company operated the La Fonda Hotel for years.
When touring Santa Fe, you will want to note the plaque near the southeast corner of the plaza which commemorates the site of the very end of the Santa Fe Trail. Across the street from the marker is the historic La Fonda Hotel which was once a Harvey House hotel and also marks the end of the Trail.